8th International Granulation Conference

Gamlen Instruments will be exhibiting at the 8th International Granulation Workshop on 28th-30th June, 2017. Hosted by the University of Sheffield, the granulation conference will highlight the latest developments in granulation and particle technology. The Granulation Conference is the ideal forum in which to demonstrate Gamlen Instrument’s high performance D …

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Structure and tablet properties of paracetamol granules prepared in fluidized bed and by wet massing

Authors MJ Gamlen, H Seager and JK Warrack Beecham Pharmaceuticals – Research division Biosciences Research Centre, Epsom, Surrey, UK Summary The structure of granules prepared by fluidized bed granulation and by wet massing, have been compared using a solvent extraction technique and scanning electron microscopy. The properties of tablets prepared …

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Predicting effects of punch shapes on tableting failure using a multi-functional single-punch tablet press

Authors Takashi Osamuraa,b Yoshiko Takeuchia Risako Onoderaa Masahiro Kitamurab Yoshiteru Takahashib Kohei Taharaa Hirofumi Takeuchia* a Laboratory of Pharmaceutical Engineering, Gifu Pharmaceutical University, 1-25-4 Daigaku-Nishi, Gifu 501-1196, Japan b Pharmaceutical Technology Department, Sawai Pharmaceutical Co. Ltd, 12-34, Hiroshibacho, Suita-Shi, Osaka 564-0052, Japan Summary We previously determined “Tableting properties” by using …

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Making better tablets using a Gamlen D series and manufacturability protocol


Simplify tablet formulation evaluation with a manufacturability protocol

Video illustrates how development of a manufacturability protocol for laboratory use is an important process of developing tablet formulations and improving tablet quality.

The manufacturability protocol developed for use on the Gamlen D series can be used throughout the lifecycle of the product from research to manufacturing, and generates key data to ensure quality on an ongoing basis.

New report reveals PROSOLV® EASYtab to be exceptional material with large capacity for dilution and excellent compaction characteristics

Report by Dr Michael Gamlen Summary The objective of this work was to establish the effect of adding a range of concentrations of ascorbic acid to PROSOLV® EASYtab, a multi-functional tableting excipient. The work was done using the Gamlen D series powder compaction analyser and included a wide range of …

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How to reduce the risk of tablet picking and sticking using the Gamlen D series

Authors Michael Gamlen and Dipankar Dey at Gamlen Tableting Limited Summary Poor lubrication results in picking and sticking problems during production. These are one of the most common causes of tablet defects which result in slow running of the tablet press and reduced output. High ejection stress (>5 MPa) is strongly …

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Gamlen Instruments: New Company Name Reflects Diverse Market Opportunities

We are excited to announce that we are changing our trading name from “Gamlen Tableting” to “Gamlen Instruments”. The change acknowledges our established global presence as a leader in bench-top powder compaction instrumentation. In addition to serving our core pharmaceutical market, Gamlen Instruments has expanded into alternative markets in food, …

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Simplify tablet formulation evaluation with a manufacturability profile

by Michael Gamlen Gamlen Tableting Ltd, Biocity Nottingham, Pennyfoot Street, Nottingham NG1 1GF Summary Development of a manufacturability protocol for laboratory use is an important process of developing tablet formulations and managing tablet quality. The manufacturability protocol developed for use on a simple laboratory instrument can be used throughout the …

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Strong interest in Gamlen D series at European Pharmaceutics Conference

Gamlen Instruments exhibited at the recent 2nd European Pharmaceutics Conference in Kraków, Poland. Visitors from across Europe expressed great interest in the D series powder compaction analyzer, attracted by the simplicity of the Gamlen® Manufacturability Assessment. The Gamlen® Manufacturability Assessment enables users to make a simple assessment of powder properties …

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Application studies using the Gamlen D series at an excipient manufacturer’s laboratory

    Key purpose: Formulation screening before transfer to rotary press – saving material. Four studies include:   Correlation of Gamlen D series and Romaco Kilian Pressima Rotary Press Application in formulation development (lubricant optimization) Analysis of SiO2 addition to excipient and testing tablet hardness Analysis of elastic recovery and …

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Early processability assessments during product development can help identify optimal API for efficient processing

Downstream processability of crystal habit-modified active pharmaceutical ingredient   Authors Nawin Pudasaini† Pratik P Upadhyay† Christian R Parker‡ Stefan U Hagen‡ Andrew D Bond†§ and Jukka Rantanen*† †Department of Pharmacy, Faculty of Health and Medical Sciences, University of Copenhagen, Universitetsparken 2, Copenhagen, Denmark ‡Syntese A/S, Industriholmen 11-13, Hvidovre, Denmark §Department …

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