Making better tablets using a Gamlen D series and manufacturability protocol

 

Simplify tablet formulation evaluation with a manufacturability protocol

Video illustrates how development of a manufacturability protocol for laboratory use is an important process of developing tablet formulations and improving tablet quality.

The manufacturability protocol developed for use on the Gamlen D series can be used throughout the lifecycle of the product from research to manufacturing, and generates key data to ensure quality on an ongoing basis.

New report reveals PROSOLV® EASYtab to be exceptional material with large capacity for dilution and excellent compaction characteristics

Report by Dr Michael Gamlen Summary The objective of this work was to establish the effect of adding a range of concentrations of ascorbic acid to PROSOLV® EASYtab, a multi-functional tableting excipient. The work was done using the Gamlen D series powder compaction analyser and included a wide range of …

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How to reduce the risk of tablet picking and sticking using the Gamlen D series

Authors Michael Gamlen and Dipankar Dey at Gamlen Tableting Limited Summary Poor lubrication results in picking and sticking problems during production. These are one of the most common causes of tablet defects which result in slow running of the tablet press and reduced output. High ejection stress (>5 MPa) is strongly …

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Simplify tablet formulation evaluation with a manufacturability profile

by Michael Gamlen Gamlen Tableting Ltd, Biocity Nottingham, Pennyfoot Street, Nottingham NG1 1GF Summary Development of a manufacturability protocol for laboratory use is an important process of developing tablet formulations and managing tablet quality. The manufacturability protocol developed for use on a simple laboratory instrument can be used throughout the …

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Early processability assessments during product development can help identify optimal API for efficient processing

Downstream processability of crystal habit-modified active pharmaceutical ingredient   Authors Nawin Pudasaini† Pratik P Upadhyay† Christian R Parker‡ Stefan U Hagen‡ Andrew D Bond†§ and Jukka Rantanen*† †Department of Pharmacy, Faculty of Health and Medical Sciences, University of Copenhagen, Universitetsparken 2, Copenhagen, Denmark ‡Syntese A/S, Industriholmen 11-13, Hvidovre, Denmark §Department …

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Gamlen Tableting to exhibit at the 2016 AAPS Annual Meeting and Exposition

Gamlen Tableting will be exhibiting at the forthcoming American Association of Pharmaceutical Scientists Annual Meeting and Exposition (AAPS 2016), 13th-17th November, at the Colorado Convention Center, Denver (Booth Number 868). We will be demonstrating Gamlen Tableting’s new manufacturability protocol which utilises data captured by the Gamlen D Series Powder Compaction …

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Dr Michael Gamlen speaks about innovative Gamlen tablet press at ManxBioMed Bio Business Conference 2013

Since then the Gamlen tablet press has been developed into 3 key products:

1. Gamlen M series for small scale tablet manufacturing

Custom small-batch tablet manufacturing with portable benchtop flexibility for your laboratory or manufacturing facility.
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2. Gamlen R series for entry level research and development

Tableting research and development systems for scientists in academia and industry.
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3. Gamlen D Series For Advanced Research And Development

Advanced Tableting Research With Affordable In-Die Dynamic Compaction Analysis For Industry And Academic Professionals.
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Comparison of the tensile fracture stress of ammonium sulfate crystals and tablets

Authors Michael Gamlen Gamlen Tableting Ltd Biocity Nottingham, Pennyfoot Street, Nottingham NG1 1GF, UK J M Newton Dept of Mechanical Engineering, University College London, London, UK P Stanley Wilsmlow, Cheshire, UK Purpose Successful modelling of the compaction properties of a material require a knowledge of both bulk material and tablet …

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Advancing powder compaction analysis
with the new Gamlen D series

Designed for advanced tableting research, Gamlen Tableting’s new flagship D series dynamic powder compaction analysers feature dwell time control from 90ms to 60sec. D series analysers are supplied with new ‘in-die’ and ‘out-of-die’ compaction analysis software that generates tablet detachment and ejection data with full profiles including strain data, Heckel …

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Influence of physicomechanical properties of starches on their tabletability – A multivariate analysis

Out of the six different grades of starches studied PURE-DENT® B830 and SPRESS® B818 showed better tabletability regardless of similar MC and amorphous nature. The better tabletability of these two starches might be attributed to their better plasticization due to loosely bound associated water, and low elastic recovery in the …

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