Development of orodispersible minitablets with lorazepam using Gamlen R series (formerly Gamlen Tablet Press GTP-1)

by Hanna Kotłowska and Małgorzata Sznitowska
Department of Pharmaceutical Technology, Medical University of Gdańsk,
Al. Hallera 107, 80-416 Gdańsk, Poland


Introduction

Lorazepam is commonly used for sedation in pediatric and neonatal intensive care units and in the treatment of status epilepticus. However, for children under 12 years of age, injection is the only available marketed preparation. In pharmaceutical practice compounded suspensions prepared from powdered lorazepam tablets are prescribed.

The aim of the study was to develop orodispersible minitablets (ODmT) with lorazepam as an acceptable and age-appropriate pediatric dosage form. They can be easily swallowed even by infants because of their small sizes and rapid disintegration in the mouth.

Besides, the properties of minitablets prepared with a single punch laboratory tableting machine and with rotary press were compared to demonstrate potential problems with product development.

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