Predicting effects of punch shapes on tableting failure using a multi-functional single-punch tablet press

Authors

Takashi Osamuraa,b
Yoshiko Takeuchia

Risako Onoderaa
Masahiro Kitamurab
Yoshiteru Takahashib
Kohei Taharaa
Hirofumi Takeuchia*

a Laboratory of Pharmaceutical Engineering, Gifu Pharmaceutical University, 1-25-4 Daigaku-Nishi, Gifu 501-1196, Japan
b Pharmaceutical Technology Department, Sawai Pharmaceutical Co. Ltd, 12-34, Hiroshibacho, Suita-Shi, Osaka 564-0052, Japan


Summary

We previously determined “Tableting properties” by using a multi-functional single-punch tablet press Gamlen R series (formerly GTP-1). We proposed plotting “Compactability” on the x-axis against “Manufacturability” on the y-axis to allow visual evaluation of “Tableting properties”. Various types of tableting failure occur in commercial drug production and are influenced by the amount of lubricant used and the shape of the punch.

We used the Gamlen R series (formerly GTP-1) to measure “Tableting properties” with different amounts of lubricant and compared the results with those of tableting on a commercial rotary tableting machine. Tablets compressed with a small amount of lubricant showed bad “Manufacturability,” leading to sticking of powder on punches. We also tested various punch shapes. The Gamlen R series (formerly GTP-1) correctly predicted the actual tableting results for all punch shapes. With punches that were more likely to cause tableting failure, our system predicted the effects of lubricant quantity in the tablet formulation and the occurrence of sticking in the rotary tableting machine.

 

Download full paper: Predicting effects of punch shapes on tableting failure
using a multi-functional single-punch tablet press
(Scroll down document list to date of post: 6 June 2017)

 

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