Helping you make better tablets using advanced material testing

Small scale tablet manufacture

For over a century pharmaceutical manufacturers struggled with powder compression problems such as capping and lamination, powder sticking to punch surfaces or die wall, and insufficient mechanical strength to withstand stress in downstream processing. We thought you’d like to know that we have created a new laboratory tablet testing service…

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New tablet testing method predicted tableting failure at the commercial scale and will prove useful for scaling up production

Formulation design of granules prepared by wet granulation method using the Gamlen R series to avoid tableting failures   Authors Takashi Osamura, Yoshiko Takeuchi, Risako Onodera, Masahiro Kitamura, Yoshiteru Takahashi, Kohei Tahara, Hirofumi Takeuchi Abstract We previously determined “Tableting properties” by using a multi-functional single-punch tablet press (GTP-1). We plotted…

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Taking the guesswork out of tablet manufacturing assessments

Most tablet formulations are developed and manufactured on a large scale without any objective assessment of their ability to form tablets, or whether they are adequately lubricated. With the latest tablet presses measuring both of these parameters, as well as a third critical quality attribute (CQA) – punch sticking (or…

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ABL&E appointed to represent Gamlen Instruments

Gamlen Instruments has appointed ABL&E as the exclusive distributor for Gamlen Instruments in parts of Central and Eastern Europe. ABL&E is a specialist distributor of pharmaceutical laboratory equipment focused on pharmaceutical testing, medicinal chemistry and the life sciences. Based in Hungary, ABL&E has a network of offices and partners that…

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Think what it would mean if you could test your tablet materials and know:

Small scale tablet manufacture

1. Your formulation works 2. Your material is the same quality as previous batches   We’re launching a new laboratory tablet testing service to help you predict and avoid manufacturing problems such as over-compaction, capping and sticking. This will speed up your manufacturing process, reduce material costs and save you…

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8th International Granulation Conference

Gamlen Instruments will be exhibiting at the 8th International Granulation Workshop on 28th-30th June, 2017. Hosted by the University of Sheffield, the granulation conference will highlight the latest developments in granulation and particle technology. The Granulation Conference is the ideal forum in which to demonstrate Gamlen Instrument’s high performance D…

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Structure and tablet properties of paracetamol granules prepared in fluidized bed and by wet massing

Authors MJ Gamlen, H Seager and JK Warrack Beecham Pharmaceuticals – Research division Biosciences Research Centre, Epsom, Surrey, UK Summary The structure of granules prepared by fluidized bed granulation and by wet massing, have been compared using a solvent extraction technique and scanning electron microscopy. The properties of tablets prepared…

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Predicting effects of punch shapes on tableting failure using a multi-functional single-punch tablet press

Authors Takashi Osamuraa,b Yoshiko Takeuchia Risako Onoderaa Masahiro Kitamurab Yoshiteru Takahashib Kohei Taharaa Hirofumi Takeuchia* a Laboratory of Pharmaceutical Engineering, Gifu Pharmaceutical University, 1-25-4 Daigaku-Nishi, Gifu 501-1196, Japan b Pharmaceutical Technology Department, Sawai Pharmaceutical Co. Ltd, 12-34, Hiroshibacho, Suita-Shi, Osaka 564-0052, Japan Summary We previously determined “Tableting properties” by using…

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Making better tablets with the Gamlen Dashboard

 

The Gamlen Dashboard – Real time powder compaction analysis 

The Gamlen Dashboard offers real-time powder compaction and tablet tensile analysis to expedite the evaluation and characterization of APIs, excipients and solid state formulations for optimal performance and scalability.

Generating live data within minutes, the unique Gamlen Dashboard system displays and interprets compaction data automatically with no user intervention.

Saving extensive calculation and analysis time, the Dashboard requires the manufacture of only 3-5 tablets, therefore also saving and conserving valuable materials whilst generating results that enable decisive action – quickly and simply.

Combining the principles of QbD with advanced benchtop Powder Compaction technology and expert analysis, Gamlen instruments offer unique accessibility, affordability, and ease-of-use.

New report reveals PROSOLV® EASYtab to be exceptional material with large capacity for dilution and excellent compaction characteristics

Report by Dr Michael Gamlen Summary The objective of this work was to establish the effect of adding a range of concentrations of ascorbic acid to PROSOLV® EASYtab, a multi-functional tableting excipient. The work was done using the Gamlen D series powder compaction analyser and included a wide range of…

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How to reduce the risk of tablet picking and sticking using the Gamlen D series

Authors Michael Gamlen and Dipankar Dey at Gamlen Tableting Limited Summary Poor lubrication results in picking and sticking problems during production. These are one of the most common causes of tablet defects which result in slow running of the tablet press and reduced output. High ejection stress (>5 MPa) is strongly…

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Gamlen Instruments: New Company Name Reflects Diverse Market Opportunities

We are excited to announce that we are changing our trading name from “Gamlen Tableting” to “Gamlen Instruments”. The change acknowledges our established global presence as a leader in bench-top powder compaction instrumentation. In addition to serving our core pharmaceutical market, Gamlen Instruments has expanded into alternative markets in food,…

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