Structure and tablet properties of paracetamol granules prepared in fluidized bed and by wet massing

Authors

MJ Gamlen, H Seager and JK Warrack
Beecham Pharmaceuticals – Research division
Biosciences Research Centre, Epsom, Surrey, UK


Summary

The structure of granules prepared by fluidized bed granulation and by wet massing, have been compared using a solvent extraction technique and scanning electron microscopy. The properties of tablets prepared from compression mixes of the granules have also been examined.

Small but significant differences were observed in both granules and tablets. The binder in both granule types was present as a sponge-like matrix, but the distribution of binder in the fluidized bed granules was less uniform than in the wet massed product.

The fluidized bed granules contained surface patches of binder and compressed to form tablets of improved tensile strength. The fluidized bed granules were more porous than the wet massed granules, and tablets prepared from the fluidized system had improved disintegration and dissolution characteristics.

 

Introduction

Seager has proposed that granules of different structure are produced when powders are granulated using the four most commonly used granulation techniques. The structure and properties of granules prepared by three of these methods have been reported recently.

In this paper, the characteristics of paracetamol granules prepared by fluidized bed granulation and by wet massing are compared using hydrolysed gelatin (Protein ‘S’) as the binder.

 

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prepared in fluidized bed and by wet massing

(Scroll down document list to date of post: 23 June 2017)

 

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