Helping you make better tablets using advanced material testing

Small scale tablet manufacture

For over a century pharmaceutical manufacturers struggled with powder compression problems such as capping and lamination, powder sticking to punch surfaces or die wall, and insufficient mechanical strength to withstand stress in downstream processing. We thought you’d like to know that we have created a new laboratory tablet testing service…

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Taking the guesswork out of tablet manufacturing assessments

Most tablet formulations are developed and manufactured on a large scale without any objective assessment of their ability to form tablets, or whether they are adequately lubricated. With the latest tablet presses measuring both of these parameters, as well as a third critical quality attribute (CQA) – punch sticking (or…

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Think what it would mean if you could test your tablet materials and know:

Small scale tablet manufacture

1. Your formulation works 2. Your material is the same quality as previous batches   We’re launching a new laboratory tablet testing service to help you predict and avoid manufacturing problems such as over-compaction, capping and sticking. This will speed up your manufacturing process, reduce material costs and save you…

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Making better tablets using a Gamlen D series and manufacturability protocol

 

Simplify tablet formulation evaluation with a manufacturability protocol

Video illustrates how development of a manufacturability protocol for laboratory use is an important process of developing tablet formulations and improving tablet quality.

The manufacturability protocol developed for use on the Gamlen D series can be used throughout the lifecycle of the product from research to manufacturing, and generates key data to ensure quality on an ongoing basis.

New report reveals PROSOLV® EASYtab to be exceptional material with large capacity for dilution and excellent compaction characteristics

Report by Dr Michael Gamlen Summary The objective of this work was to establish the effect of adding a range of concentrations of ascorbic acid to PROSOLV® EASYtab, a multi-functional tableting excipient. The work was done using the Gamlen D series powder compaction analyser and included a wide range of…

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How to reduce the risk of tablet picking and sticking using the Gamlen D series

Authors Michael Gamlen and Dipankar Dey at Gamlen Tableting Limited Summary Poor lubrication results in picking and sticking problems during production. These are one of the most common causes of tablet defects which result in slow running of the tablet press and reduced output. High ejection stress (>5 MPa) is strongly…

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Simplify tablet formulation evaluation with a manufacturability profile

by Michael Gamlen Gamlen Tableting Ltd, Biocity Nottingham, Pennyfoot Street, Nottingham NG1 1GF Summary Development of a manufacturability protocol for laboratory use is an important process of developing tablet formulations and managing tablet quality. The manufacturability protocol developed for use on a simple laboratory instrument can be used throughout the…

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Early processability assessments during product development can help identify optimal API for efficient processing

Downstream processability of crystal habit-modified active pharmaceutical ingredient   Authors Nawin Pudasaini† Pratik P Upadhyay† Christian R Parker‡ Stefan U Hagen‡ Andrew D Bond†§ and Jukka Rantanen*† †Department of Pharmacy, Faculty of Health and Medical Sciences, University of Copenhagen, Universitetsparken 2, Copenhagen, Denmark ‡Syntese A/S, Industriholmen 11-13, Hvidovre, Denmark §Department…

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Gamlen Tableting to exhibit at the 2016 AAPS Annual Meeting and Exposition

Gamlen Tableting will be exhibiting at the forthcoming American Association of Pharmaceutical Scientists Annual Meeting and Exposition (AAPS 2016), 13th-17th November, at the Colorado Convention Center, Denver (Booth Number 868). We will be demonstrating Gamlen Tableting’s new manufacturability protocol which utilises data captured by the Gamlen D Series Powder Compaction…

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Comparison of the tensile fracture stress of ammonium sulfate crystals and tablets

Authors Michael Gamlen Gamlen Tableting Ltd Biocity Nottingham, Pennyfoot Street, Nottingham NG1 1GF, UK J M Newton Dept of Mechanical Engineering, University College London, London, UK P Stanley Wilsmlow, Cheshire, UK Purpose Successful modelling of the compaction properties of a material require a knowledge of both bulk material and tablet…

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Advancing powder compaction analysis
with the new Gamlen D series

Designed for advanced tableting research, Gamlen Tableting’s new flagship D series dynamic powder compaction analysers feature dwell time control from 90ms to 60sec. D series analysers are supplied with new ‘in-die’ and ‘out-of-die’ compaction analysis software that generates tablet detachment and ejection data with full profiles including strain data, Heckel…

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Influence of physicomechanical properties of starches on their tabletability – A multivariate analysis

Out of the six different grades of starches studied PURE-DENT® B830 and SPRESS® B818 showed better tabletability regardless of similar MC and amorphous nature. The better tabletability of these two starches might be attributed to their better plasticization due to loosely bound associated water, and low elastic recovery in the…

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