New tablet testing method predicted tableting failure at the commercial scale and will prove useful for scaling up production

Formulation design of granules prepared by wet granulation method using the Gamlen R series to avoid tableting failures   Authors Takashi Osamura, Yoshiko Takeuchi, Risako Onodera, Masahiro Kitamura, Yoshiteru Takahashi, Kohei Tahara, Hirofumi Takeuchi Abstract We previously determined “Tableting properties” by using a multi-functional single-punch tablet press (GTP-1). We plotted…

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Predicting effects of punch shapes on tableting failure using a multi-functional single-punch tablet press

Authors Takashi Osamuraa,b Yoshiko Takeuchia Risako Onoderaa Masahiro Kitamurab Yoshiteru Takahashib Kohei Taharaa Hirofumi Takeuchia* a Laboratory of Pharmaceutical Engineering, Gifu Pharmaceutical University, 1-25-4 Daigaku-Nishi, Gifu 501-1196, Japan b Pharmaceutical Technology Department, Sawai Pharmaceutical Co. Ltd, 12-34, Hiroshibacho, Suita-Shi, Osaka 564-0052, Japan Summary We previously determined “Tableting properties” by using…

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Characterization of tableting properties measured with a multi-functional compaction instrument for several pharmaceutical excipients and actual tablet formulations

Authors Takashi Osamuraa,b Yoshiko Takeuchia Risako Onoderaa Masahiro Kitamurab Yoshiteru Takahashib Kohei Taharaa Hirofumi Takeuchia,* a Laboratory of Pharmaceutical Engineering, Gifu Pharmaceutical University, 1-25-4 Daigaku-Nishi, Gifu 501-1196, Japan b Pharmaceutical Technology Department, Sawai Pharmaceutical Co. Ltd, 12–34, Hiroshibacho, Suita-Shi, Osaka 564-0052, Japan Summary Before designing tablet formulations, it is important…

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Development of orodispersible minitablets with lorazepam using Gamlen R series (formerly Gamlen Tablet Press GTP-1)

by Hanna Kotłowska and Małgorzata Sznitowska Department of Pharmaceutical Technology, Medical University of Gdańsk, Al. Hallera 107, 80-416 Gdańsk, Poland Introduction Lorazepam is commonly used for sedation in pediatric and neonatal intensive care units and in the treatment of status epilepticus. However, for children under 12 years of age, injection…

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How to remove the guess work from formulation and preformulation studies and better understand compaction

Watch R series video Quickly compare materials and formulations Ideal for investigating tableting problems Measures compaction and ejection profiles for every tablet Simple to operate Study lubrication behaviour Test small quantities of material down to 10 mg Produce multi-layer and dry coated tablets Compaction data automatically exported to Excel Learn…

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