Accurate and reliable measurement of tablet detachment and ejection forces using Gamlen Tablet Press

by Michael Gamlen and Dipankar Dey at Gamlen Tableting Limited The effect of lubricant concentration on tabletability, tablet ejection and detachment can be evaluated using the Gamlen Tablet Press. Lubricant effectiveness rank order varies between materials; some materials are better lubricated by sodium stearyl fumarate than by magnesium stearate. Detachment…

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Why material compressibility assessments are essential to tablet drug development and manufacture

by Michael Gamlen and Dipankar Dey at Gamlen Tableting Limited Study demonstrates importance of material compressibility assessments in tablet drug development and manufacture. Material compressibility (the inherent capability to tablet) influences drug substance properties such as adsorption, dissolution rate as well as hardness and friability. Using a Gamlen Tablet Press,…

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How to formulate tablets on a small scale using the Gamlen Tablet Press

by Michael Gamlen at Gamlen Tableting Limited Characterisation of the compaction process is an important element of tablet development. Better understanding of tablet compression and ejection behaviour is essential for generation of data needed to support requirements of Quality by Design. It will help establish a more robust and reliable…

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How to make better tablets using QbD
and the Gamlen Tablet Press

by Michael Gamlen (Gamlen Tableting) and Joe Domingue (SciMark International) The solution to reliably identifying and solving many tableting problems lies in the nature of a conventional tablet press. Single punch and rotary tablet presses work on a similar principle which is to compress material to a particular thickness. This…

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Influence of physicomechanical properties of starches on their tabletability – A multivariate analysis

Out of the six different grades of starches studied PURE-DENT® B830 and SPRESS® B818 showed better tabletability regardless of similar MC and amorphous nature. The better tabletability of these two starches might be attributed to their better plasticization due to loosely bound associated water, and low elastic recovery in the…

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What you need to know about tablet compression and the tablet manufacturing process

by Michael Gamlen and Dipankar Dey at Gamlen Tableting Limited Tablet hardness has traditionally been used as a measure of quality, but tensile strength offers greater accuracy when comparing tablets of different composition, shape and size – and compressed on different equipment. Learn how the Gamlen Tablet Press provides greater…

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How to achieve targeted delivery of the poorly soluble active ingredient dipyridamole

Study carried out using Gamlen Tablet Press Introduction The poor physicochemical properties of many drugs present challenges when targeting delivery to site-specific regions of the gastrointestinal tract for either a systemic or topical effect. For poorly soluble basic drugs administered by the oral route, often delivery in a salt form…

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How to improve tablet manufacturing process using rapid formulation assessments

Study carried out using Gamlen Tablet Press   Introduction Tablet formulation and reformulation suffers from the issue that prior design is difficult based on present knowledge. A critical attribute of a formulation is not routinely tested – namely its compressibility. In this paper we present a systematic approach to tablet…

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Study results produced on Gamlen R series (formerly Gamlen Tablet Press) are scalable to high speed Fette production press

Comparison of 100mg of two particular formulations (obtained from a major pharma company) compacted on the Gamlen Tablet Press (GTP-1) showed matching results when compared with production data obtained on a high speed rotary tablet press (Fette 2090) Analysis of tablet tensile strength to compaction pressure and solid fraction demonstrated…

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Gamlen Tablet Press improves tablet development process

by Michael Gamlen and Dipankar Dey at Gamlen Tableting Limited Tablets under pressure The hardness of a tablet has traditionally been used as a measure of quality; however, tensile strength is more appropriate when comparing tablets of different composition, shape and size, and compressed on different pieces of equipment. The…

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How to make the right decisions about drug suppliers and their suitability

Study carried out using Gamlen Tablet Press A client asked us to evaluate two raw material suppliers in respect of compressibility and batch to batch variability. Samples of two batches of Supplier 1 material were compressed (without any processing or the addition of lubricant). Compressibility of the two batches was…

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Reducing risk in tablet development and manufacture

Study carried out using Gamlen Tablet Press This article describes how measuring material properties that relate directly to the final tablet product, including the inherent ability of materials to form tablets (compressibility) reduces the overall risk in tablet development and manufacture. A case study illustrates the benefits of rapid compressibility…

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Study shows Gamlen Tablet Press (GTP-1) accurately predicts tablet properties

Earlier this month Powder Technology published an article co-authored by the team at Gamlen Tableting and researchers at GSK UK. The article entitled “compression prediction accuracy from small scale compaction studies to production presses” examines how compaction and ejection force measurement using the revolutionary GTP-1 press at small scale can predict tablet properties on a production scale tablet press.

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Why you need to understand Critical Quality Attributes in order to optimise the manufacturing process

Study carried out using Gamlen Tablet Press It is important that tablet properties such as tablet hardness be compared in a meaningful way when comparing formulations particularly when the tablets are compacted on different pieces of equipment. The properties of a tablet, both during manufacturing and in vivo, are determined…

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Gamlen Tablet Press in Japan!

Once again I am in Japan to support the Gamlen Tablet Press with our great Japanese distributors the NihonValidation Technology Corporation.  They have been working hard to generate data for potential customers, who have been impressed by the simplicity of the instrument’s operation. Next week we are visiting customers and…

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