New tablet testing method predicted tableting failure at the commercial scale and will prove useful for scaling up production

Formulation design of granules prepared by wet granulation method using the Gamlen R series to avoid tableting failures   Authors Takashi Osamura, Yoshiko Takeuchi, Risako Onodera, Masahiro Kitamura, Yoshiteru Takahashi, Kohei Tahara, Hirofumi Takeuchi Abstract We previously determined “Tableting properties” by using a multi-functional single-punch tablet press (GTP-1). We plotted…

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Taking the guesswork out of tablet manufacturing assessments

Most tablet formulations are developed and manufactured on a large scale without any objective assessment of their ability to form tablets, or whether they are adequately lubricated. With the latest tablet presses measuring both of these parameters, as well as a third critical quality attribute (CQA) – punch sticking (or…

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Structure and tablet properties of paracetamol granules prepared in fluidized bed and by wet massing

Authors MJ Gamlen, H Seager and JK Warrack Beecham Pharmaceuticals – Research division Biosciences Research Centre, Epsom, Surrey, UK Summary The structure of granules prepared by fluidized bed granulation and by wet massing, have been compared using a solvent extraction technique and scanning electron microscopy. The properties of tablets prepared…

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Predicting effects of punch shapes on tableting failure using a multi-functional single-punch tablet press

Authors Takashi Osamuraa,b Yoshiko Takeuchia Risako Onoderaa Masahiro Kitamurab Yoshiteru Takahashib Kohei Taharaa Hirofumi Takeuchia* a Laboratory of Pharmaceutical Engineering, Gifu Pharmaceutical University, 1-25-4 Daigaku-Nishi, Gifu 501-1196, Japan b Pharmaceutical Technology Department, Sawai Pharmaceutical Co. Ltd, 12-34, Hiroshibacho, Suita-Shi, Osaka 564-0052, Japan Summary We previously determined “Tableting properties” by using…

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Making better tablets with the Gamlen Dashboard

 

The Gamlen Dashboard – Real time powder compaction analysis 

The Gamlen Dashboard offers real-time powder compaction and tablet tensile analysis to expedite the evaluation and characterization of APIs, excipients and solid state formulations for optimal performance and scalability.

Generating live data within minutes, the unique Gamlen Dashboard system displays and interprets compaction data automatically with no user intervention.

Saving extensive calculation and analysis time, the Dashboard requires the manufacture of only 3-5 tablets, therefore also saving and conserving valuable materials whilst generating results that enable decisive action – quickly and simply.

Combining the principles of QbD with advanced benchtop Powder Compaction technology and expert analysis, Gamlen instruments offer unique accessibility, affordability, and ease-of-use.

New report reveals PROSOLV® EASYtab to be exceptional material with large capacity for dilution and excellent compaction characteristics

Report by Dr Michael Gamlen Summary The objective of this work was to establish the effect of adding a range of concentrations of ascorbic acid to PROSOLV® EASYtab, a multi-functional tableting excipient. The work was done using the Gamlen D series powder compaction analyser and included a wide range of…

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How to reduce the risk of tablet picking and sticking using the Gamlen D series

Authors Michael Gamlen and Dipankar Dey at Gamlen Tableting Limited Summary Poor lubrication results in picking and sticking problems during production. These are one of the most common causes of tablet defects which result in slow running of the tablet press and reduced output. High ejection stress (>5 MPa) is strongly…

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Simplify tablet formulation evaluation with a manufacturability profile

by Michael Gamlen Gamlen Tableting Ltd, Biocity Nottingham, Pennyfoot Street, Nottingham NG1 1GF Summary Development of a manufacturability protocol for laboratory use is an important process of developing tablet formulations and managing tablet quality. The manufacturability protocol developed for use on a simple laboratory instrument can be used throughout the…

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Strong interest in Gamlen D series at European Pharmaceutics Conference

Gamlen Instruments exhibited at the recent 2nd European Pharmaceutics Conference in Kraków, Poland. Visitors from across Europe expressed great interest in the D series powder compaction analyzer, attracted by the simplicity of the Gamlen® Manufacturability Assessment. The Gamlen® Manufacturability Assessment enables users to make a simple assessment of powder properties…

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Application studies using the Gamlen D series at an excipient manufacturer’s laboratory

    Key purpose: Formulation screening before transfer to rotary press – saving material. Four studies include:   Correlation of Gamlen D series and Romaco Kilian Pressima Rotary Press Application in formulation development (lubricant optimization) Analysis of SiO2 addition to excipient and testing tablet hardness Analysis of elastic recovery and…

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Early processability assessments during product development can help identify optimal API for efficient processing

Downstream processability of crystal habit-modified active pharmaceutical ingredient   Authors Nawin Pudasaini† Pratik P Upadhyay† Christian R Parker‡ Stefan U Hagen‡ Andrew D Bond†§ and Jukka Rantanen*† †Department of Pharmacy, Faculty of Health and Medical Sciences, University of Copenhagen, Universitetsparken 2, Copenhagen, Denmark ‡Syntese A/S, Industriholmen 11-13, Hvidovre, Denmark §Department…

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What you didn’t know about breakage of anisotropic rod-shaped particles

Authors: V Penkavova1*, L Kulaviak1, MC Ruzicka1, M Puncochar2, P Zamostny3 1 Department of Multiphase Reactors, Institute of Chemical Process Fundamentals, Czech Academy of Sciences, Prague, Czech Republic, 2 Environmental Process Engineering Laboratory, Institute of Chemical Process Fundamentals, Czech Academy of Sciences, Prague, Czech Republic, 3 Department of Organic Technology,…

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Characterization of tableting properties measured with a multi-functional compaction instrument for several pharmaceutical excipients and actual tablet formulations

Authors Takashi Osamuraa,b Yoshiko Takeuchia Risako Onoderaa Masahiro Kitamurab Yoshiteru Takahashib Kohei Taharaa Hirofumi Takeuchia,* a Laboratory of Pharmaceutical Engineering, Gifu Pharmaceutical University, 1-25-4 Daigaku-Nishi, Gifu 501-1196, Japan b Pharmaceutical Technology Department, Sawai Pharmaceutical Co. Ltd, 12–34, Hiroshibacho, Suita-Shi, Osaka 564-0052, Japan Summary Before designing tablet formulations, it is important…

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Development of orodispersible minitablets with lorazepam using Gamlen R series (formerly Gamlen Tablet Press GTP-1)

by Hanna Kotłowska and Małgorzata Sznitowska Department of Pharmaceutical Technology, Medical University of Gdańsk, Al. Hallera 107, 80-416 Gdańsk, Poland Introduction Lorazepam is commonly used for sedation in pediatric and neonatal intensive care units and in the treatment of status epilepticus. However, for children under 12 years of age, injection…

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Comparison of the tensile fracture stress of ammonium sulfate crystals and tablets

Authors Michael Gamlen Gamlen Tableting Ltd Biocity Nottingham, Pennyfoot Street, Nottingham NG1 1GF, UK J M Newton Dept of Mechanical Engineering, University College London, London, UK P Stanley Wilsmlow, Cheshire, UK Purpose Successful modelling of the compaction properties of a material require a knowledge of both bulk material and tablet…

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How to make a good tablet
and avoid common tableting problems

Determining whether a powder will form a good tablet is a complex process because for a material to make a good tablet it requires a number of different attributes which in some ways conflict with each other. For example it needs to be well lubricated but also to be easily…

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Learn the two key methodologies that can help you better assess the tabletability of pharmaceutical powder formulations

Article published by Tablets & Capsules May 2016 Authors: Joe Domingue, SciMark International and Michael Gamlen, Gamlen Tableting   Scientists tasked with formulating and manufacturing robust yet effective tablets face many challenges. These include: ✓ Optimizing tablets during early stages of development when access to affordable and easy-to-use tools is…

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