Gamlen Tablet Press GTP-1
The all-in-one tablet press and powder compaction analyser

GTP-1

 

 

Much more than a tablet press
The Gamlen Tablet Press is much more than a tablet press. It’s a strategic analysis instrument which removes the guess work from preformulation studies. We call it Tableting by Design.

 

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Computer controlled for detailed analysis
The revolutionary Gamlen Tablet Press provides precise data using tiny amounts of material. It’s ideal for research and development and small laboratory production runs.


Quick and easy to operate

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A major breakthrough in pharmaceutics teaching and research

 

Using the GTP, the student can quickly see the difference in the compressibility and lubrication properties of different excipients, processes and formulations. This makes it ideal for both teaching and research. Features and benefits include:

  • The only instrumented laboratory tablet press suitable for student use
  • Simple to use with unique measurement capabilities
  • Measures all key parameters of the tablet compaction process
  • Suitable for undergraduate use and postgraduate research
  • New technology means that most data generated is suitable for publication
  • Integrated system for the study of tablets – used for tablet compaction AND tablet fracture

Read full article: Helping you maintain your leading edge in pharmaceutics teaching and research


Study proves Gamlen Tablet Press can simulate conditions
on Fette 2090 rotary press

 

Comparison of 100mg of two particular formulations (obtained from a major pharma company) compacted on the GTP-1 showed matching results when compared with production data obtained on a high speed rotary press (Fette 2090). Analysis of tablet tensile strength to compaction pressure and solid fraction demonstrated that the results obtained on the GTP-1 can be reproduced for different sizes and shapes of tablets produced on a rotary press.
Read full article: Study results produced on Gamlen Tablet Press are scalable to high speed Fette production press


Helping you create better tablets

 

To create new and better tablets you need to study and understand the relationship between drug properties, formulation and manufacturing process under properly controlled laboratory conditions.

Until recently small scale tablet manufacture using ‘controlled compaction force’ had not been possible because of technical limitations based on thickness control and large scale production. This made it difficult to make tablets or evaluate materials under tightly controlled conditions.

Revolutionary Gamlen Tablet Press and powder compaction analyser

Dr Michael Gamlen invented the revolutionary Gamlen Tablet Press to solve this problem. The GTP allows you to make tablets on a small scale, using controlled compaction force and at very low wastage rates, normally less than 1%. This force determines both the physical strength and the dissolution behaviour of the tablet. These are the key properties which ensure the tablet reaches the patient and delivers the drug.

The GTP works by monitoring the force in real time using a PLC. Punch force and punch position are displayed on a computer which is also used to input the compaction conditions. Using the GTP you can make tablets of extraordinary reproducibility and consistency, within 1-2% force variation. Batch yields are >99%.

For the measurement of tablet breaking load, the press records both force and displacement during compression and fracture, and also provides the ejection force profile associated with tablet ejection.

Much more than a tablet press

The GTP is much more than a tablet press. It’s a strategic analysis instrument which provides precisely the data necessary to make informed decisions.

In the scale-up of tablet production, the GTP can be used to determine the relationship between tablets developed at the benchtop scale using a few grams of material (often at early development stage) and the final tablet manufactured on a rotary tablet press. The latter uses hundreds of kilograms of material, making process development difficult because of practical difficulties in experimentation; smaller and differently-shaped tablets can, however, be scaled to the final desired tablet design if TFS is utilised as the basis for comparison.

If you want new and better tablet products and processes, then you need the Gamlen Tablet Press.


Gamlen Tablet Press GTP-1 overview

 

Unique benefits include:

  • Complete control of compaction process using compression force or tablet thickness with live display of punch position and compaction force
  • Quick and easy to use with tiny amounts of material
  • Precise measurement of tablet detachment force which is ideal for lubricant selection and optimisation studies
  • Generates punch displacement measurements to assist with analysis of the compaction process, and the measurement of the three key compaction properties – tabletability, compressibility and compactibility
  • Can be programmed to perform repeated compaction and pre-compaction to simulate conditions on Fette 2090 rotary press
  • Demonstrated to accurately simulated production press compaction behaviour for several material types
  • Operating range 0-5kN, 1-60mm/minute. Punch sizes 2-15mm
  • Improves tablet manufacturing process
  • Very low wastage rates, normally less than 1%
  • Being able to check product quality prior to putting batches onto production presses
  • Cheaper than compaction force simulator
  • Can be used in controlled humidity environment
  • Saves time, money and materials

Using the Gamlen Tablet Press you’ll be able to:

 

  • Quickly compare formulations
  • Produce multi-layer and dry coated tablets
  • Test small quantities of material down to 10mg
  • Study lubrication behaviour
  • Manufacture preclinical and phase 1 product
  • Ideal for investigating tableting problems

Applications

 

  • Manufacture of test product batches
  • Pre-formulation studies
  • Formulation comparisons
  • Salt selection studies
  • Intrinsic dissolution studies
  • Excipient compatibility samples
  • Manufacture of phase one clinical trials material

Quick and easy to operate

 

The Gamlen Tablet Press offers a quick route to the manufacture of small batches of tablets under tightly controlled conditions.

Sample powders (we recommend using the Powder Pipette – accuracy ±2% or better for most materials).


Performance

 

  1. Manufacturing rate approximately 1 tablet per minute.
  2. The product can be manufactured under completely controlled compaction conditions including compaction rate and compaction force (all tablets) and temperature and humidity (when used with glove box).
  3. Doses as low as 10mg, lower in some cases.
  4. Product yield essentially 100% – NO LOSS of valuable or scarce products.
  5. Fracture measurement- the press can change mode to hardness tester to measure tablet tensile strength

Specification

 

Choice of 4 output units Kilogram (kg) as standard; Kilopond (kp), Newton (N) or Pound (lb) on request
Maximum load 500 kg, 500 kp, 5000 N or 999.9 lb respectively
Load resolution 0.1 kg, 0.1 kp, 1 Newton or 0.1 lb respectively
Minimum detectable fracture load 3 kg (adjustable)
Width between pillars 60 mm
Load Cell travel 30 mm
Test Height Depends on pillar extension lengthMaximum extension of 300 mm
Load indication Via PC software
Inputs & Outputs USB interfaceLoad cell
Test Speed Range 0.1 – 60 mm/min.
High down and return speed 60 mm/min
Calibration Dead weights in kg or proving ring.
Power requirements 110/120 VAC 1.6 A or220/240 VAC 3.15 A(External selection via fuse holder)
Machine dimensions 310(w) x 270(d) x 375(h)
Machine weight (without accessories) 16 kg
Shipping size 390 x 350 x 390 or 460 x 430 x 480
Shipping weight approx 20 kg

Read more about the Gamlen Tablet Press GTP-1 features and benefits


GamPette-cutoutThe GamPette

 

We recommend using the GamPette to dispense accurate quantities (better than 2%) of powder into the die reproducibly.

The GamPette is a hand held powder pipette that accurately dispenses solids, comprising a dispensing handle and a controller unit. Tip sizes are available to accommodate a wide range of powder volumes. Powder is drawn into the pipette tip in the handle under vacuum and then expelled under light positive pressure.

Learn more about the GamPette

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