Influence of physicomechanical properties of starches on their tabletability – A multivariate analysis

Out of the six different grades of starches studied PURE-DENT® B830 and SPRESS® B818 showed better tabletability regardless of similar MC and amorphous nature. The better tabletability of these two starches might be attributed to their better plasticization due to loosely bound associated water, and low elastic recovery in the decompression phase.

VS Dave, St John Fisher College, Wegmans School of Pharmacy
M Chanda, Campbell University College of Pharmacy and Health Sciences
M Sayles, St John Fisher College, Wegmans School of Pharmacy
M Popielarczyk, St John Fisher College, Wegmans School of Pharmacy
H Boyce University of Maryland
SK Bompelliwar, Campbell University College of Pharmacy and Health Sciences
RV Haware, Campbell University College of Pharmacy and Health Sciences

Purpose

The goal of this study was to identify correlations between the physicomechanical properties of different grades of starches with their tabletability.

Methods

Corn-starch grades (PURE-DENT® B700, PURE-DENT® B810, and PURE-DENT® B830) and pregelatinized corn-starchgrades (SPRESS® B818, SPRESS® B820, and SPRESS® B825) were studied for physicomechanical properties, dynamicsorption isotherm, moisture content [MC] (% w/w), dehydration enthalpy (J/g) [ΔHd], and percent crystallinity (%). Tablets (6 mm) were compressed from hand-weighed powders (constant true volume) using Gamlen Tablet Press (Compression pressure-100 MPa; Compression speed- 5mm/s, 50 mm/s). Tablet mechanical strength (TMS) and Heckel parameters were evaluated. Correlation between physicomechanical properties and compression descriptors was evaluated by multivariate method.

Gamlen-Tablet-Press-laborat

 

 

 

 

 

 

 

 

 

Why use a Gamlen Tablet Press?

It can save you time, money and materials. People need help to study tablets under properly controlled conditions in a laboratory.

Michael Gamlen invented the Gamlen Tablet Press (GTP) to help you understand the relationship between the properties of your drug, formulation, and manufacturing process. When you do this you can develop better products more quickly, and improve productivity of your tablet manufacturing operations.

The GTP is the first machine designed to make tablets on a small scale at a user-specified compaction force. This force determines both the physical strength and the dissolution behaviour of the tablet. These are the key properties which ensure the tablet reaches the patient and delivers the drug.

The machine works by monitoring the force in real time using a PLC.  The punch force and punch position are displayed in real time on a computer which is also used to input the compaction conditions. Using the GTP we make tablets of extraordinary reproducibility and consistency, within 1-2% force, and with no wastage. Batch yields are >99%.

For the measurement of tablet breaking load, the press records both force and displacement during both compression and fracture, and also provides the ejection force profile associated with tablet ejection

In the scale-up of tablet production, the press can be used to determine the relationship between tablets developed at the bench-top scale using a few grams of material (often at the early development stage) and the final tablet manufactured on a rotary tablet press. The latter uses hundreds of kilograms of material, making process development difficult because of practical difficulties in experimentation; smaller and different shaped tablets can, however, be scaled to the final desired tablet design if TFS is used as the basis for comparison.

If you want better tablet products and processes you need the Gamlen Tablet Press.

Results

All starches followed Type-III sorption isotherm with open hysteresis loop indicating their large amorphous content. High amorphous content was further confirmed with hollow diffraction peaks of starches in the powder X-ray diffraction studies. Glass transition temperature of all starches was about 101°C. The moisture content and percent crystallinity of all starches was found statistically insignificant.

However, PURE-DENT® B830 and SPRESS® B818 showed significantly low ΔHdvalues. Principle component analysis (PCA) loadings plot calculated with measured physicomechanical properties and TMS showed positive correlation between high Heckel Yield pressure values of plastic and elastic deformation and negative correlation with percent crystallinity, ΔHd, and MC along PC1. These relationships confirmed expected phenomenon in PCA score plots that Starches (PURE-DENT® B830 and SPRESS® B818) with plastic deformation followed by low elastic recovery in the decompression phase shows better tabletability. Furthermore, positive correlation of low ΔHd with TMS might indicate that starches with easy availability of associated water (low ΔHd) might have better tabletability due to water induced material plasticization.

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fig2

 

 

 

 

 

 

 

 

 

 

 

Conclusion

Out of the six different grades of starches studied PURE-DENT® B830 and SPRESS® B818 showed better tabletability regardless of similar MC and amorphous nature. The better tabletability of these two starches might be attributed to their better plasticization due to loosely bound associated water, and low elastic recovery in the decompression phase.

Have a question? Like a quotation?
Like to see a Gamlen Tablet Press demo or have batch tablet samples made?
Then email michael.gamlen@gamlentableting.com
or call us now on +44 115 912 4271

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