Authors: Joe Domingue, SciMark International and Michael Gamlen, Gamlen Tableting
Scientists tasked with formulating and manufacturing robust yet effective tablets face many challenges.
✓ Optimizing tablets during early stages of development when access to affordable and easy-to-use tools is limited
✓ Identification of critical quality attributes (CQAs)
✓ Characterization of the suitability and batch-to-batch tolerances of key excipients
✓ Accessing API-excipient and excipient-excipient compatibilities
✓ Determining critical process parameters
This article highlights a comprehensive tablet exam protocol that combines dynamic powder compactions analysis with tensile fracture stress measurement of the resulting tablet.
Together these measurements provide a fast, affordable and highly predictive measurement of the ultimate tabletablity of a pharmaceutical powder formulation.
They also provide unique real-time insights into the compaction process.
Download full article: Tablet analysis – Tablet exam: using dynamic compaction analysis to ensure successful formulations (Scroll down to case studies on download page)