Development of orodispersible minitablets with lorazepam using Gamlen R series (formerly Gamlen Tablet Press GTP-1)

by Hanna Kotłowska and Małgorzata Sznitowska Department of Pharmaceutical Technology, Medical University of Gdańsk, Al. Hallera 107, 80-416 Gdańsk, Poland Introduction Lorazepam is commonly used for sedation in pediatric and neonatal intensive care units and in the treatment of status epilepticus. However, for children under 12 years of age, injection…

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Gamlen Tableting exhibiting at the 11th Central European Symposium on Pharmaceutical Technology

Gamlen Tableting is exhibiting at the 11th Central European Symposium on Pharmaceutical Technology in Belgrade, Serbia (CESPT 2016), 22nd-24th September 2016, where delegates will have the opportunity to see a demonstration of Gamlen D series instrument. The Gamlen D series delivers advanced tableting research and in-die dynamic compaction analysis, enabling…

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Comparison of the tensile fracture stress of ammonium sulfate crystals and tablets

Authors Michael Gamlen Gamlen Tableting Ltd Biocity Nottingham, Pennyfoot Street, Nottingham NG1 1GF, UK J M Newton Dept of Mechanical Engineering, University College London, London, UK P Stanley Wilsmlow, Cheshire, UK Purpose Successful modelling of the compaction properties of a material require a knowledge of both bulk material and tablet…

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Gamlen Tableting exhibiting at 7th APS International PharmSci Conference, 5th-7th September 2016

Gamlen Tableting will be exhibiting at the 7th APS International PharmSci Conference, 5th-7th September 2016, at the new Technology and Innovation Centre at the University of Strathclyde, Glasgow (Stand Number 16). On display will be the Gamlen D Series Powder Compaction Analyzer, designed for industry and academic professionals undertaking advanced…

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Gamlen Tableting exhibiting at the American Association of Colleges of Pharmacy (AACP) annual meeting 2016

Gamlen Tableting will be exhibiting at the American Association of Colleges of Pharmacy (AACP) annual meeting, 23rd-27th July, California, USA. Tablets are the most widely used pharmaceutical dosage form, so understanding the fundamentals of compaction science is an important part of the educational process. Gamlen Tableting offers a range of…

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How to make a good tablet
and avoid common tableting problems

Determining whether a powder will form a good tablet is a complex process because for a material to make a good tablet it requires a number of different attributes which in some ways conflict with each other. For example it needs to be well lubricated but also to be easily…

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New GamTech video series launched

Gamlen Tableting has launched a new series of GamTech videos entitled “Tablet development made easy”. Accessible through the Gamlen Tableting website, the series will discuss the key principles of tableting, how to address common tableting issues and how to investigate the compaction process. Michael Gamlen, Gamlen Tableting, explains: “The first episode in the…

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Learn the two key methodologies that can help you better assess the tabletability of pharmaceutical powder formulations

Article published by Tablets & Capsules May 2016 Authors: Joe Domingue, SciMark International and Michael Gamlen, Gamlen Tableting   Scientists tasked with formulating and manufacturing robust yet effective tablets face many challenges. These include: ✓ Optimizing tablets during early stages of development when access to affordable and easy-to-use tools is…

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GamTech video series – What is the compaction triangle?

This video explains how the relationships between compaction pressure, tensile strength and solid fraction are studied using the compaction triangle.

Tablet hardness, or breaking strength, is an important and widely used parameter to control the tablet manufacturing process. In many cases it is used as a surrogate measure for compression force during manufacture, particularly if the tablet press is unable to measure compression force.

It is an important control parameter because compression affects every tablet property including disintegration, dissolution and friability. In some cases stability is also affected.

Watch video for full explanation

Advancing powder compaction analysis
with the new Gamlen D series

Designed for advanced tableting research, Gamlen Tableting’s new flagship D series dynamic powder compaction analysers feature dwell time control from 90ms to 60sec. D series analysers are supplied with new ‘in-die’ and ‘out-of-die’ compaction analysis software that generates tablet detachment and ejection data with full profiles including strain data, Heckel…

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Gamlen Tableting attending 31st Annual Meeting of the Academy of Pharmaceutical Science and Technology, Japan, 19th-21st May 2016

Dr Michael Gamlen, Gamlen Tableting, will be attending the 31st Annual Meeting of the Academy of Pharmaceutical Science and Technology in Gifu, Japan, in partnership with Nihon Validation Technologies Corporation, Gamlen Tableting’s exclusive distributor in Japan. Michael commented: “The Gamlen range of powder compaction analyzers has attracted a truly global…

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How to remove the guess work from formulation and preformulation studies and better understand compaction

Watch R series video Quickly compare materials and formulations Ideal for investigating tableting problems Measures compaction and ejection profiles for every tablet Simple to operate Study lubrication behaviour Test small quantities of material down to 10 mg Produce multi-layer and dry coated tablets Compaction data automatically exported to Excel Learn…

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