The purpose of this study was to enhance tablet release rate using Alcell lignin, a non-conventional bio-based excipient. Here, a Gamlen Powder Compaction Analyser is used to produce tablets for disintegration and dissolution testing. This work demonstrates some of the capabilities of a Gamlen instrument beyond that of compaction analysis. The Gamlen was ideally suited to this type of study as it allows for complete control over tableting conditions while requiring minimal sample volumes and producing virtually no material waste.
These results demonstrate the potential to use lignin, a natural material, to enhance the bioavailability of poorly water-soluble drugs.