Pharmaceutical scientists endorse Gamlen R series
(formerly GTP-1)

“One of the problems in creating the course is designing an experiment that will deliver reproducible results so that the students can generate models from the data.
During trialling, we quickly found that the Gamlen R series generated consistent results and allowed control of variables which made the Gamlen R series an ideal tool to teach the important course principles.
Experiments were conducted repeatedly over the two consecutive days of the course and were found to generate the same data. To get our course objectives across, it was imperative that we could rely on the experiment to work and the Gamlen R series gave us that reproducibility.
If errors occurred, something had gone wrong in the experiment itself i.e. errors were errors – not random noise in the data. This was important as it supported the material we were teaching.”
Professor Patrick Steel, Durham University

 

Gamlen R series tablet presses have been used to demonstrate the use of statistical methodologies of Principal Components Analysis (PCA) and Design of Experiments (DoE) in a workshop on understanding and optimising chemical processes.

GTP R-series

Gamlen R series

Delivered by the Industrial Statistics Research Unit (ISRU), Newcastle University and the Department of Chemistry, Durham University, the Gamlen R series model was used during practical sessions to produce tabletability data.

Professor Patrick Steel, Durham University, explains: “As part of the course we conducted a laboratory experiment. One of the problems in creating the course is designing an experiment that will deliver reproducible results so that the students can generate models from the data.

We were keen to choose a chemistry orientated experiment – with tablet-making there are a number of variables that can be controlled such as the speed of the press, the composition of the tablet and the compaction force. These are all variables that we could adjust fairly easily in the lab experiment. During trialling, we quickly found that the Gamlen R series generated very consistent results and allowed control of variables which made the Gamlen R series an ideal tool to teach the important course principles.

Experiments were conducted repeatedly over the two consecutive days of the course and were found to generate the same data. To get our course objectives across, it was imperative that we could rely on the experiment to work and the Gamlen R series gave us that reproducibility. If errors occurred, something had gone wrong in the experiment itself i.e. errors were errors – not random noise in the data. This was important as it supported the material we were teaching.”

The Gamlen R series tablet press is easy to use, with novice users requiring as little as 30 minutes training to be able to control the basic functions of the instrument. Ideal for undergraduate teaching and the academic research market, the Gamlen R series is an entirely computer-controlled portable laboratory instrument that enables understanding and experimentation with the relationship between the properties of substances, the composition of a formulation and the manufacturing process.


“The Gamlen R series allows you to understand the relationship between the properties of substances, the composition of a formulation and the manufacturing process. Another useful Gamlen R series feature is that it allows determination of tablet hardness across a range of sizes. With this information, the production process can be optimised easily and faster whilst using only small amounts of material.” Professor Sznitowska, The Department of Applied Pharmacy, Medical University of Gdansk, Poland.

 

The Department of Applied Pharmacy, Medical University of Gdansk, Poland, has recently published a review of the Gamlen R series. Researchers led by Professor Margaret Sznitowska are using the Gamlen R series to analyse and understand the relationship between properties of materials and process conditions when manufacturing mini-tablets.

GTP in use at the University of Gdansk

Gamlen R series in use at the University of Gdansk

Published in Świat Przemysłu Farmaceutycznego (The World of the Pharmaceutical Industry), the article recommends that the Gamlen R series is ideal for conducting formulation research as well as being an excellent teaching tool. The Gamlen R series enables the user to easily introduce variations in compressibility or formulation and measure the impact on product quality.

The team at MUG conducted a study comparing direct compaction of powders containing Loratidine and established that the Gamlen R series quickly provides information about the quality of material from different suppliers – whilst using less than 1g of material.

Professor Sznitowska commented: “The Gamlen R series allows you to understand the relationship between the properties of substances, the composition of a formulation and the manufacturing process. Another useful Gamlen R series feature is that the press allows determination of tablet hardness across a range of sizes. With this information, the production process can be optimised easily and faster whilst using only small amounts of material.”


“I find the Gamlen R series very useful for teaching undergraduate students the principles of tablet compression because of its easy operation and favourable size for benchtop placement.”
Dr Petr Zámostný, Associate Professor, Department of Organic Technology, University of Chemistry and Technology, Prague.

 

The University of Chemistry and Technology, Prague, is now using the Gamlen R series for both tablet compression research and undergraduate teaching.

Dr Petr Zámostný

Dr Petr Zámostný, Associate Professor, Department of Organic Technology, explains how the Gamlen R series is now being used in current research programmes at the University: “The Gamlen R series helps us to speed up tablet compression screening in reformulation projects aimed at replacing the wet granulation by roller compaction and I am looking forward to the Gamlen R series helping us in our research project involving the study of glidant action during the secondary compression of dry-granulated product.”

A small machine, with a footprint similar to an A4 sheet of paper, the Gamlen R series is safe to use and less complex than a full-scale tablet press; properties that are beneficial in an educational environment.

“I find the Gamlen R series very useful for teaching undergraduate students the principles of tablet compression because of its easy operation and favourable size for benchtop placement” added Dr Zámostný.

U Chem Tech(CZ) -Gamlen GTP-1-on lab bench-laptopThe Gamlen R series is designed to operate in three easy steps; the user simply weighs the powder into a die using a conventional balance, compresses the tablet and then ejects the finished product ready for use. Entirely computer-controlled, it works at punch speeds of 1 mm/ second using a V-shape compression wave form. It can compress from 2 mg to 400 mg of material at punch sizes from 2 mm to 13 mm in diameter depending on the tablet weight.

 


“We were impressed with the way the Gamlen R series could simulate a number of conditions that real tablet production involves, without requiring high volumes. For a teaching environment, we need to be able to manufacture small batches, at high frequency and by various different users and this machine has been able to meet these needs.”
Dr Daryl Williams, Imperial College London.

 

Imperial College London, one of the world’s leading universities, is putting industry at the heart of its courses once again, with the investment in the Gamlen R series for the new Discovery Space in the Chemical Engineering Department.

The new Discovery Space Laboratories, Chemical Engineering, Imperial College London

The new Discovery Space Laboratories, Chemical Engineering, Imperial College London

The Gamlen R series has been selected by the college to raise the standards of tablet production teaching – both in terms of supporting teaching practices and creating ‘real life’ student experiences.

The machine was purchased to meet the needs of the university’s 4 year, MEng degree in Chemical Engineering and has been installed in the Discovery Space, a new suite of teaching laboratories. Located in the year three laboratory, the Gamlen R series is allowing professors and students to replicate small scale tablet production both simply and quickly, under conditions that are similar to full scale production. The combination of these factors being an integral reason the Chemical Engineering Department purchased the machine. Commenting on the decision, Dr Daryl Williams, Director of the Discovery Space said:

Dr Daryl Williams (right) in the Discovery Space Laboratories.

Dr Daryl Williams (right) in the Discovery Space Laboratories.

“We were impressed with the way the Gamlen R series could simulate a number of conditions that real tablet production involves, without requiring high volumes. For a teaching environment, we need to be able to manufacture small batches, at high frequency and by various different users and this machine has been able to meet these needs”.

The Gamlen R series has been fully integrated into the practical teaching methods of the course and is currently being used to demonstrate dissolution profiles of paracetamol. The students are required to make a tablet and then compare the dissolution profiles with those they purchase over the counter. Being able to guarantee quality levels in tablet production was another prerequisite to the purchasing decision and Dr Daryl Williams was impressed with the quality produced from the Gamlen R series.  He continues: “Previously we had made the tablets with a manual press, but the quality was poor. The Gamlen R series has been able to guarantee quality and give us reproducible results, every time, helping us drive our standards up.” A small machine with a footprint the size of a PC, the Gamlen R series is intrinsically very safe and is nowhere near the complexity of a full scale tablet press. This is particularly beneficial in an educational environment and was highlighted at the Discovery Space laboratories, where students were trained to use the machine in 15 minutes and within half an hour they were able to use it to make a tablet. Making theory a reality in a very short space of time and integral to the success of any teaching practice.

Summarising on the acquisition of its Gamlen R series, Dr Daryl Williams concludes: “Our students find the machine very easy to use, it makes good quality tablets, in a cost effective manner and allows for reproducible results. A winning combination. Part of our mission is to try and give our students a ‘near industrial’ experience and most of the facilities they use in the Discovery Laboratory are industrial type equipment. Sometimes this is not possible, be it for space or finance, but when you have a small scale equivalent that behaves in a similar way, such as The Gamlen R series, we know we are still providing industry relevant equipment, facilities and teaching”.

The Gamlen R series is designed to operate in three easy steps; the user simply weighs the powder into a die using a conventional balance, compresses the tablet and then ejects the finished product ready for use. Entirely computer controlled, it works at punch speeds of 0.1mm/ second using a V-shape compression wave form. It can compress from 2-400mg of material at punch sizes from 2-13mm in diameter depending on the tablet weight required. The compression load is pre-set and reproducible ±1% between compressions.

The Gamlen R series offers almost unlimited applications in the pharmaceutical industry, as well as potential markets including nuclear, medical diagnostics, ceramics and nanomolecular industries.

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