Tablet development & manufacturing services
Accelerating tablet development from concept to commercial production
At BetterTablets, we help pharmaceutical companies bring tablet formulations to market faster, more efficiently and with greater confidence. From early feasibility studies through to commercial-scale production, we’ve got your back.
Expertise you can rely on
From a handful of tablets to a batch of over one million
Our unique expertise in powder compaction, formulation development and tablet manufacture enables us to support your project at every stage. We deliver scientifically robust solutions backed by regulatory expertise and industry-leading technology.
1
tablet — our smallest coating and development batch
1M+
tablets in a single commercial-scale production batch
GLP
standards with full electronic LIMS traceability
Our services
Support at every stage of tablet development
Why choose BetterTablets?
A complete service, built on quality
Service 01
Formulation development
Our comprehensive formulation development service is currently focused on direct compression and roller compaction processes. By combining advanced micro-formulation techniques with Gamlen Powder Compaction Analysis technology, we dramatically reduce API requirements during development. This helps to lower costs, minimise material use and accelerate project timelines.
Our approach is particularly valuable for high-value or limited-availability drug substances, because it allows informed formulation decisions to be made based on the USP <1062> compaction monograph using only very small quantities of material. Our studies include roller compaction, lubricant sensitivity and blend uniformity studies as needed.
Service 02
Small-scale film coating
As part of our complete service, we provide flexible film coating services for projects of all sizes. We offer the capability to coat as little as a single tablet. This unique capability is ideal for formulation screening, proof-of-concept studies and early-stage product development, eliminating the need for large development batches.
Service 03
Powder characterisation
Our process begins with a detailed characterisation of the drug substance, including measurement of absolute density, particle size distribution by laser diffraction, and shear cell and tapped/bulk density where enough material is available.
Measuring the USP <1062> compaction properties of the API helps identify possible issues with the API and its process suitability. These measurements, combined with the expected dose of drug required in the tablet, inform the initial formulation selection of direct compression or roller compaction.
Service 04
Process development
Scale-up and process development of direct compression and roller compaction is relatively straightforward, and is carried out in conjunction with the client’s — or their CDMO’s — process development team.
Key to success is ensuring that the compaction conditions identified at small scale are maintained during scale-up. This is facilitated by our laboratory Comil, which we use for the roller compaction milling step during formulation development and which is the industry standard for this stage of the process.
Service 05
Analytical development & compatibility studies
Robust analytical methods are fundamental to successful product development. It’s why we offer:
These services help ensure your formulation is stable, reliable and ready for progression through development and regulatory approval.