Understanding the implication of Kawakita model parameters using in-die force displacement curve analysis for compacted and non-compacted API powders

Here at Gamlen we are highlighting some of the fascinating and ground-breaking research that has been carried out by our customers in our Paper of the Month posts.

The authors of Gamlen’s April Paper of the Month present a simplified method of estimating Kawakita compression parameters. They achieve this by analysing compaction force-displacement curves which are the raw data output from the Gamlen Powder Compaction Analyser.

They achieve this by analysing compaction force-displacement curves which are the raw data output from the Gamlen Powder Compaction Analyser.
  • Compaction analysis was carried out using a Gamlen on six different APIs. Non-processed and roller compacted forms of each API were analysed.
  • A comparison of the force-displacement data with a re-arranged form of the Kawakita equation showed significant similarity.

CONCLUSION

The authors found that the force displacement curves generated using a Gamlen instrument can be used to estimate the Kawakita compression parameters Pk and a. Where a is the maximum powder volume reduction and Pk is the pressure required to achieve half the max. volume reduction. This significantly reduces the amount of experimental work required to determine Kawakita parameters compared to the traditional approach.

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