Compaction and tableting properties of composite particles of microcrystalline cellulose and crospovidone engineered for direct compression.

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In this paper the authors investigate the compaction behaviour of a co-processed excipient (CPE) using a Gamlen Powder Compaction Analyser.

  • Co-processing, a particle engineering technique, was used to produce composite particles of microcrystalline cellulose (MCC) and crospovidone (CPV).
  • Compaction analysis was carried out on the MCC, CPV and the co-processed particles using a Gamlen.
  • Heckel and Kawakita plots were generated for each material as well as tabletability, compactibility and compressibility data.
  • Formulated tablets were produced by direct compression from MCC and the co-processed particles using metronidazole as a model drug.
  • The lubricant sensitivity and the dilution potential of the co-processed excipient was assessed and the properties of the formulated tablets were evaluated.
Figure 4, Drug release profile of MCC, CPE, PME, and Prosolv showing the amount of drug released with time

CONCLUSION

The co-processed particles yielded tablets with enhanced dissolution and drug release profiles compared to MCC. This study illustrates the potential to use co-processing to improve the tableting properties of excipients.

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