Compaction and tableting properties of composite particles of microcrystalline cellulose and crospovidone engineered for direct compression.
Here at Gamlen we are highlighting some of the fascinating and ground-breaking research that has been carried out by our customers in our Paper of the Month posts.
In this paper the authors investigate the compaction behaviour of a co-processed excipient (CPE) using a Gamlen Powder Compaction Analyser.
Co-processing, a particle engineering technique, was used to produce composite particles of microcrystalline cellulose (MCC) and crospovidone (CPV).
Compaction analysis was carried out on the MCC, CPV and the co-processed particles using a Gamlen.
Heckel and Kawakita plots were generated for each material as well as tabletability, compactibility and compressibility data.
Formulated tablets were produced by direct compression from MCC and the co-processed particles using metronidazole as a model drug.
The lubricant sensitivity and the dilution potential of the co-processed excipient was assessed and the properties of the formulated tablets were evaluated.
The co-processed particles yielded tablets with enhanced dissolution and drug release profiles compared to MCC. This study illustrates the potential to use co-processing to improve the tableting properties of excipients.
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Four speakers will discuss topics related to their experience of using of Gamlen instruments. It will be an opportunity to gain a deeper understanding of the benefits of compaction analysis and the applications of Gamlen Instruments. Register for our FREE Gamlen User Group online event today.
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