Effect of lignin on the release rate of acetylsalicylic acid tablets

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The purpose of this study was to enhance tablet release rate using Alcell lignin, a non-conventional bio-based excipient. Here, a Gamlen Powder Compaction Analyser is used to produce tablets for disintegration and dissolution testing. This work demonstrates some of the capabilities of a Gamlen instrument beyond that of compaction analysis. The Gamlen was ideally suited to this type of study as it allows for complete control over tableting conditions while requiring minimal sample volumes and producing virtually no material waste.

Acetylsalicylic acid formulations - Lignin Tablet and No Lignin tablet
  • Two acetylsalicylic acid (aspirin) formulations were prepared by dry granulation, one with and one without the presence of Alcell lignin.
  • A Gamlen Powder Compaction Analyser was to produce tablets of each formulation in fixed load mode.
  • Hardness, disintegration and dissolution tests were carried out on the resultant tablets.
  • The addition of lignin to the formulation was found to improve the critical quality attributes of the tablets; the lignin tablets displayed greater tablet hardness, faster disintegration, and improved release rate.
  • The authors state that the observed improved tablet characteristics of the lignin tablets are due to the amorphous nature of the lignin and its interaction with the API, acetylsalicylic acid.
  • The impact of the roller compaction parameters used during the dry granulation process was also investigated.

CONCLUSION

These results demonstrate the potential to use lignin, a natural material, to enhance the bioavailability of poorly water-soluble drugs.

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