Scanning electron micrographs of recrystallised ibuprofen showing changes in particle habit from; a) hexane b) toluene c) acetonitrile d) ethanol. All images captured using Å~100 magnification and scale bar is 100 μm.
The authors successfully linked the processing, structure, properties, and performance of Ibuprofen, demonstrating the central principle of Materials Science as described by the Materials Science tetrahedron. “The increase in the specific energy component is shown to correlate with the sticking propensity of ibuprofen. It is proposed that investigation of the chemical causality of sticking, for this API and others, using the techniques demonstrated in this paper will be of increasing importance.”
Note: In the paper the authors use a handheld device in combination with a Gamlen GTP-1 to measure detachment stress values. Our D-series instruments now feature an integrated detachment force measurement system, so these measurements are automatically taken immediately after compaction.