This month’s paper investigates the effect of reworking MCC on its compaction behaviour with some surprising results. To do this, the authors repeatedly subjected MCC to roller compaction. They then used a Gamlen Powder Compaction Analyser to carry out Heckel and Kawakita compaction behaviour assessments after each roller compaction cycle.
Figure 5: SEM of non-compacted Avicel PH-101 01. (A), roller compacted Avicel-1st compaction. (C), and roller compacted Avicel-3rd compaction cycle (D) at magniﬁcation of 3000×.compaction cycle
Figure 2. Bulk density as a function of compaction cycles
Intensified roller compaction can be employed to improve MCC powder compactibility This could facilitate reworking or reprocessing of MCC in tablet making.